Altered IFN-γ Levels after Treatment of Epileptic Patients with Omega-3 Fatty Acids

Soudeh Ghafouri-Fard, Mahnaz Hashemi, Mahboobeh Rafigh, Mohammad Amin Omrani, Bashdar Mahmud Hussen, Arezou Sayad, Mohammad Taheri

      • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
      • 2Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
      • 3Medical Genetics Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
      • 4Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran.
      • 5Pharmacognosy Department, College of Pharmacy, Hawler Medical University, Erbil, Iraq.
      • 6Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ar.sayad@yahoo.com.
      • 7Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohammad_823@yahoo.com.

      Abstract

      Epilepsy is a frequent chronic disorder of the brain characterized by intermittent epileptic seizures caused by hypersynchronous discharge of neurons in the brain. Studies have reported the role of cytokines in the pathogenesis of epilepsy, and a number of investigations have shown decreased levels of omega-3 fatty acids in epileptic patients. We investigated differences in serum levels of two cytokines, transforming growth factor (TGF)-β and interferon (IFN)-γ, in 40 epileptic cases prior to and after treatment with omega-3 fatty acids. IFN-γ levels were significantly increased after the 16-week treatment period (P < 0.001). However, TGF-β levels remained unchanged (P = 0.14). Omega-3 fatty acid treatment may alter the immune response in epileptic patients. This should be considered in prescription of omega-3 fatty acid supplements in these patients. Future studies with larger sample sizes should verify the results of the current study.

      Keywords: Epilepsy; IFN-γ; Omega-3 fatty acid; TGF-β.