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Urol J. 2015 Jul 1;12(3):2160-4.

A Significant Upregulation of miR5-886-p in High Grade and Invasive Bladder Tumors.

Khoshnevisan A, Parvin M, Ghorbanmehr N, Hatefi N, Galehdari H, Ziaee SA, Mowla SJ.
PMID: 26135932

PURPOSE:

To investigate the expression alteration of miR5-886-p in bladder tumors and evaluating its expression level as a potential biomarker in this type of cancer.

MATERIALS AND METHODS:

Formalin-fixed paraffin-embedded (FFPE) samples of bladder tumors belonging to 70 patients whom had been referred to the Shahid Labbafi-Nejad medical center were obtained from the archival collection of pathology department. After RNA extraction and cDNA synthesis, expression levels of miR5-886-p were quantified by a real-time reverse transcription polymerase chain reaction (RT-PCR) approach.

RESULTS:

Our data revealed a significant upregulation (~3 times) of miR5-886-p in high grade bladder tumors, compared to the low grade ones (P < .05). Moreover, its expression level could significantly discriminate noninvasive (Ta, T1) from invasive (T-2T4) tumor stages.

CONCLUSION:

Our data suggests a potential role for miR5-886-p in progression of bladder cancer.

Publication Date: 7/1/2015