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Urol J. 2012 Fall;9(4):691-9

Association of G/A Polymorphism, rs266882, in AREI Region of the Prostate-Specific Antigen Gene with Prostate Cancer Risk and Clinicopathological Features

Samzadeh M, Hasanzad M, Jamaldini SH, Haghdoost AA, Afshari M, Ziaee SA
PMID: 23235975

PURPOSE: To determine the association of prostate-specific antigen (PSA) 158A/G polymorphism with clinicopathologic characteristics of the disease and prostate cancer (PCa) risk. MATERIALS AND METHODS: Two hundred and six subjects, including 95 patients with PCa and 111 subjects with benign prostatic hyperplasia (BPH), were recruited in this study. Genotyping was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method. RESULTS: Presence of GG genotype significantly increased the risk of PCa more than 2-fold compared to AG genotype (adjusted odds ratio = 2.4; P = .03). The percentages of G alleles of polymorphisms in patients with PCa were more than that in ones with BPH (odds ratio = 1.2; P = .7). CONCLUSION: The GG genotype of PSA 158A/G polymorphism is a predisposing factor for PCa. But no association was observed between alleles and grade, stage, or age of diagnosis. Similarly, the rs266882 polymorphism was not associated with PSA plasma levels.

Publication Date: 12/15/2012